Miniaturization in freeze drying is a relevant topic due to the limited availability and costs of API, especially in early development phases. A mini-freeze dryer (LyoCapsule™) consists of a smal
Webinar Category: Freeze-Drying
Lyophilization of Diagnostics: The Challenges of Formulation, Cycle Development and Container-Closure Selection
Diagnostic reagents tend to be reactive in nature, which of course is what makes them useful, but it also means it can be challenging to stabilize them sufficiently to endow them with a long enough
Trehalose Sucrose and Glycerol in Freeze-Drying and Storage Stability of Mycobacterium Bovis
The prerequisite of cold chain storage is a challenge for the global vaccination effort. For tuberculosis, live attenuated M. bovis, marketed as BCG vaccine is the only FDA-approved vaccine against
Modelling Inter-Vial Intra-Batch Variation of Primary Drying Time from the Natural Variation in Freeze-Drying Process Variables
The product temperature during primary drying can vary from vial to vial within a single batch. Several sources of the heterogeneity of product temperature and drying time have been well characteri
Predictive Models of Lyophilization Process for Development, Scale-Up, Technology Transfer, and Manufacturing
Scale-up and technology transfer of lyophilization processes are challenges that require thorough characterization of the laboratory and larger scale lyophilizers. In this work, computational fluid
Using Solid-State NMR Spectroscopy as a Tool for Developing Stable Lyophilized Protein Formulations
Solid-State Nuclear Magnetic Resonance Spectroscopy (SSNMR) is a powerful analytical tool that can be utilized in order to characterize the lyophilized matrix and predict stability in lyophilized p
Equipment Capability of Freeze Dryers and Its Relevance to the Graphical Design Space for Primary Drying
The equipment capability curve is one of two boundary conditions employed in the construction of a graphical design space to establish a relationship between process variables and product temperatu
Lyophilization of Nanomedicines – Concepts and Challenges
Lyophilization of nanoparticles has always been an elusive science. The variety of formulations of nanoparticles makes it impossible to have single cycle that would fit all types of nanoparticles.
Investigation of Heat and Mass Transfer in Freeze-Drying of Cartridges / Dual Chamber Syringes
Despite their advantages, DCS (dual chamber syringe) containers are not yet widely used, partly because no robust models yet exist that can accurately describe the freeze drying phenomena in these
Utilizing Raman Spectral Changes to Predict Lyophilized Protein Stability
Understanding of final product quality attributes in lyophilized products is of critical importance. This knowledge will improve the long term quality impact of the final product. This webinar will