The initial phase of a freeze drying process, freezing, determines the ice crystal morphology within the product. This, in turn, impacts the product`s performance in the subsequent drying phases. D
Webinar Category: Freeze-Drying
Phase Transformations During Freeze-Drying: Potential Implications on Drug Product
The phase behavior of the active pharmaceutical ingredient (API) and excipients in multi-component pharmaceutical systems, during the various stages of freeze-drying, is a complex interplay of form
Understanding Phase Separation in Amorphous Lyophilized Protein Systems
Phase separation in amorphous lyophilized systems is often speculated to be a source of physical instability, however, limited detection methods have slowed the investigation of this phenomenon. As
The Power of Simple Modeling to Facilitate Scale Up of Freeze Drying Processes: Primary Drying
It is well known that a freeze drying process developed in the laboratory does not necessarily produce the same product temperature history and product quality in manufacturing even though the same
Mechanisms by Which Crystalline Mannitol Improves the Reconstitution Time of High Concentration Lyophilized Protein
Lyophilization (freeze-drying) of high concentration protein formulations often results in cakes with long and variable reconstitution times. Presence of crystalline mannitol in the freeze-dried ca
How the Freezing Protocol Can Influence Protein Stability During Lyophilization
The variation in ice nucleation temperature and the resulting effect on process and product quality has gained increasing attention; however, little is known about how the freezing protocol post ic
Development of Foam Drying and Application to Novel Modalities
Promising novel therapeutics, such as cellular and gene therapies, present new challenges to the development of stable, dried biopharmaceutical products. Recent work has evaluated the stability of
Importance of the Heat Transfer Coefficient for the Control and Optimization of a Lyophilization Cycle
Lyophilization is a technology based on fundamental principles of phase transformations and transfers of heat and matter. Understanding these principles is necessary to develop/optimize non empir
Freeze-Drying of Cells and Tissues for Applications in Regenerative and Reproductive Medicine
In this presentation, feasibility of freeze-drying for stabilization of cells as well as decellularized heart valves will be discussed. Various methods to incorporate disaccharides into mammalian c
Case Study for Containment of HPAPI in the Freeze-Drying Process
The December LyoLearn Webinar presented by Flow Sciences Inc. in cooperation with Nektar Therapeutics, and SafeBridge Consultants, Inc.,will focus on nanogram level containment of active pharmaceut