VirTis Ultra Prime 50 R&D and Small-Batch Production Freeze Dryer

Suitable for small-batch production, the Ultra Prime 50 R&D and Small-Batch Production Freeze Dryer combines the power and efficiency of a VirTis freeze dryer with a compact size to create a customizable device perfect for enhancing your workflow, including options for up to 15 shelves, bulk or stoppering configurations, control formats and temperature and vacuum sensors, and solvent packages.

With standard options and 50 L condenser capacities, you can rest assured that there’s an Ultra Prime 50 configuration to meet your requirements.

Features & Benefits

Performance — improved refrigeration system with increased cooling capacity and lower GWP
Available with a Merlin or LyoLogic™ control systems
Space-saving — compact, free-standing mobile design frees up precious lab or clean room space
Flexible — comprehensive range of controls, shelf configurations, and vacuum pump options allows for tailored systems to meet your needs
Simple set-up — compatible with standard laboratory utilities
Innovative LyoLogic HMI — new Controls platform with increased functionality
Efficient — easy defrost/clean smooth-wall condenser minimizes turnaround time
Designed for longevity — chemical-resistant 316 stainless steel shelf design and optional stoppering ram

Applications

Specifications

Condenser Capacity

50 L
Condenser Temperature (50/60 Hz)

-85 ºC
Shelf Temperature Range

-55 ºC to 65 ºC
Configurations

standard or clean room
Number of Shelves

8 standard, up to 15
Refrigerants

R1270 & R170
Dimensions (W x D x H)

up to 890 x 1970 x 1990 mm
Weight

909 kg

Resources

Industries

Frequently Asked Questions

How does the Ultra Prime 50 differ from previous Ultra models?

The Ultra Prime 50 offers enhanced performance, upgraded GWP sustainability, and a more space-efficient design compared to earlier Ultra models.

How does the Ultra Prime 50 reduce its Global Warming Potential?

The Ultra Prime 50 uses refrigerant gases with GWPs of just 2 and 6, compared to previous systems that used gases with GWPs of 1,774 and 13,396. This major reduction reflects our commitment to sustainability and lowering environmental impact.

What process controls does the Ultra Prime 50 use?

The Ultra Prime 50 can be configured with one of two control systems: Merlin or LyoLogic.

The Merlin control system automates the drying process and manages recipes from a touchscreen, with 8 standard temperature probes, a Pirani gauge, and stoppering control. The optional Merlin Software & Workstation adds historical data trending and CSV data export.

The LyoLogic control system, built on the Copa-Data Zenon HMI/SCADA platform, supports 17 primary/secondary drying steps and 12 thermal treatment steps, up to 16 total temperature probes, and automatic Pirani/Capacitance Manometer endpoint detection. A 21 CFR Part 11 compliance ready version is also available, adding batch reporting, UPS backup, and SQL database compliance.

Is the Ultra Prime 50 suitable for GMP and regulated environments?

Yes. The LyoLogic control system is available in a 21 CFR Part 11 compliance ready version, adding e-signatures on recipe changes, a secure encrypted audit trail for events and alarms, and full security integration with the Microsoft Windows operating environment. Both Merlin and LyoLogic control systems are fully configurable and validatable for regulated pharmaceutical and biotechnology applications, with testing protocols and onsite IQ/OQ validation support.

How many temperature probes does the Ultra Prime 50 have?

8 temperature probes are included as standard, with up to 16 available on LyoLogic.

What cooling configurations does the Ultra Prime 50 support?

The Ultra Prime 50 is available in either an air-cooled or a water-cooled configuration. Air-cooled units release approximately 22,900 BTU/h of peak heat directly into the room. Water-cooled units route heat into a facility water loop (15 to 22 Lpm usage) instead, generating about 5,400 BTU/h in the room.

Is it easy to defrost and clean the Ultra Prime 50?

Yes. The Ultra Prime 50 uses hot gas defrost, which loosens ice from the condenser walls before it fully melts, so a full defrost isn't always necessary. Its smooth-walled condenser also makes routine cleaning easy and supports fast turnaround between cycles.

Can the Ultra Prime 50 process multiple vial sizes at once?

Yes. Shelf latching kits allow individual shelves to be set to different heights, so different vial sizes can be loaded on separate shelves during the same cycle. Stroke Saver spacers also keep stoppering fully seating vials even on partially loaded shelves, and shelf spacers provide additional height adjustment where needed.

Can the Ultra Prime 50 process GORE® LYOGUARD® trays?

Yes. The Ultra Prime 50 was designed for compatibility with both sizes of GORE® LYOGUARD® trays. Dedicated LYOGUARD transfer trays are also available, supporting the safe handling and loading of filled LYOGUARD containers into the freeze dryer.

What kind of training is available for operators?

We offer Remote Freeze-Drying Training and Hands-On Training Opportunities to ensure operators can effectively and sustainably utilize the Ultra Prime 50, maximize cycle efficiency, and optimize system performance.