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Hull LyoConstellation™ Small-Scale Aseptic Freeze Dryers
Hull LyoConstellation™ Small-Scale Aseptic Freeze Dryers
Hull LyoConstellation™ Small-Scale Aseptic Freeze Dryers
The newest additions to the LyoConstellation™ family, S20-A, S30-A, and S50-A, are a series of aseptic small-scale freeze dryers designed to seamlessly integrate with our aseptic autoloader, making them suitable for use in isolators and oRABS environments.
Our autoloader enhances line sterility assurance while maintaining a reduced footprint. Its compact design fits easily into existing cleanroom layouts and eliminates manual intervention, helping your team work more efficiently without adding complexity.
Features & Benefits
- Fully automated operation — enables consistent, efficient row-by-row vial loading and unloading while reducing manual intervention and human error
- Bellows-free loading pusher — eliminates hidden contamination risks by removing hard-to-clean components and preventing non-sterile parts from entering the process chamber
- First-air optimized sub-door — enhances sterility assurance by fully exposing critical surfaces during decontamination and minimizing contamination at transfer points
- Compact footprint — maximizes valuable cleanroom space with an integrated design ideal for small-batch production; for redundant configurations (compressors and vacuum circuits), a specially integrated frame optimizes space, reducing the footprint even within the freeze dryer technical area
- Seamless aseptic integration — designed for isolators and oRABS systems, enabling smooth connection with small-scale freeze dryers and fill-finish lines
- Compliance-ready design — supports cGMP (FDA & EU Annex 1), 21 CFR Part 11, GAMP5, and ASME-BPE requirements for regulatory confidence
Line of Sight™ Lyophilization & PAT Tools
To help you overcome the mounting challenges when scaling up your lyophilization processes, LyoConstellation™ lyophilizers are compatible with our state-of-the-art Line of Sight™ Lyophilization and Process Analytical Technologies (PAT) suite of scalable tools:
- LyoFlux® TDLAS — measure water vapor mass flow with accuracy during freeze-drying
- TEMPRIS® Wireless Sensors — advanced wireless temperature monitoring for the highest quality product, on budget and on time
- ControLyo® Nucleation Technology — take control of your freeze-drying with cutting-edge nucleation technology for precise control of the freezing point
Specifications
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Lowest Shelf Temperature (50/60 Hz)-60 °C
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Shelf Temperature Control Range-55 °C to 65 °C
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Number of Shelves
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S20-A4 shelves (1 radiant)
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S30-A6 shelves (1 radiant)
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S50-A9 shelves (1 radiant)
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Vial Capacity
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S20-Aup to 7,308
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S30-Aup to 12,180
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S50-Aup to 19,488
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Materials316L stainless steel
