Hull LyoConstellation S80/S100/S130 Production Lyophilizers

Our Hull LyoConstellation™ S80, S100 and S130 Production Lyophilizers build on SP’s reputation as a pioneer of freeze-drying technologies. Equipped and controlled as a production system, the LyoConstellation offers a seamless approach to scale-up while being designed for line integration. If time is not on your side, rest assured that our lyophilizers are ready to order – for faster than average market delivery.

Built for demanding lyophilization needs – Each of our units can accommodate vials up to 100 mL. You can therefore develop the most aggressive of freeze-drying cycles safe in the knowledge that you’re using a lyophilizer that works with you.

State-of-the-art lyophilization technologies – To help you overcome the mounting challenges when scaling up your lyophilization processes for development, all Hull LyoConstellation™ Production Lyophilizers are compatible with our Line of Sight™ suite of scalable lyophilization tools that incorporate Process Analytical Technologies (PAT) to automate, control, and support the lyophilization process. This guarantees efficiency, quality and consistency throughout the entire fill-finish process.

SP’s Line of Sight PAT Tools:

LyoFlux® TDLAS
Let the data guide you! Measure water vapor mass flow with accuracy during freeze-drying

SMART™ Freeze Dryer Technology
No hesitation – get instant feedback on important product data including resistance, heat flow, and mass transfer

TEMPRIS® Wireless Sensors
Advanced wireless temperature monitoring for the highest quality product – on budget and on time

ControLyo® Nucleation Technology
Take control of your freeze-drying with cutting-edge nucleation technology – for precise control of the freezing point

• Therapeutic Proteins
• ADC Production for Clinical Trials
• Medium Batch Production for Compounding Pharmacies and Pharma, Including CMO and CRO
• Diagnostics

• Taking you from start to finish – ideal for cycle development and scale-up to stability, pilot and clinical batch production, through full aseptic production
• Technologies that ensure quality – full suite of PAT tools and technologies enables Line of Sight approach in cycle development and scale-up for simplified technology transfer, assuring product safety and quality in production
• Validation made easy – validation ports in chamber and condenser as standard, with full documentation package and support available
• Accurate end points – Pirani gauge and capacitance manometer as standard
• Full Steam in Place (SIP) & Clean in Place (CIP) execution, with manual/H₂O₂ option
• Isolator ready with auto locking doors

• Hull LyoConstellation S80/S100/S130 Production Lyophilizers
• http://SP-Hull-Line-of-Sight-White-Paper-Jan22
• http://SP-Hull-LyoConstellation-S20-Spec-Sheet
• http://White-Paper-Putting-Fill-Finish-Customization-into-Your-Line-of-Sight-4
• http://SP-Hull-LyoConstellation-S30-Spec-Sheet