Hull LyoConstellation™ S80/S100/S130 Production Lyophilizers

• Taking you from start to finish — ideal for cycle development and scale-up to stability, pilot, and clinical batch production, through full aseptic production
• Technologies that ensure quality — full suite of PAT tools and technologies enables Line of Sight approach in cycle development and scale-up for simplified technology transfer, assuring product safety and quality in production
• Validation made easy — validation ports in chamber and condenser as standard, with full documentation package and support available
• Accurate end points — Pirani gauge and capacitance manometer as standard
• Built for demanding lyophilization needs — each of our units can accommodate vials up to 100 mL, so you can develop the most aggressive of freeze-drying cycles safe in the knowledge that you’re using a lyophilizer that works with you
• Full Steam in Place (SIP) & Clean in Place (CIP) execution, with manual/H₂O₂ option
• Isolator ready with auto locking doors

To help you overcome the mounting challenges when scaling up your lyophilization processes, LyoConstellation™ lyophilizers are compatible with our state-of-the-art Line of Sight™ Lyophilization and Process Analytical Technologies (PAT) suite of scalable tools:

• LyoFlux® TDLAS — measure water vapor mass flow with accuracy during freeze-drying
• SMART™ Freeze Dryer Technology — get instant feedback on important product data including resistance, heat flow, and mass transfer
• TEMPRIS® Wireless Sensors — advanced wireless temperature monitoring for the highest quality product, on budget and on time
• ControLyo® Nucleation Technology — take control of your freeze-drying with cutting-edge nucleation technology for precise control of the freezing point

• Hull LyoConstellation™ S80/S100/S130 Production Lyophilizers
• Technologies & PAT Tools to Overcome LyoChallenges — White Paper
• Putting Fill-Finish Customization into Your Line of Sight — White Paper