To enhance the sensitivity and reproducibility of LCMSMS drug screening in forensic casework, Forensic Science Ireland evaluated the Genevac EZ-2 system as an alternative to nitrogen blow-down evaporation. The centrifugal approach enabled direct drying of solid-phase extracts within collection tubes, improving analyte recovery and reducing risk of sample loss. Key topics addressed include:
- Comparative evaluation of centrifugal evaporation vs nitrogen blow-down
- Direct drying of solid-phase extracts to improve recovery
- Sensitivity improvements for controlled substances (e.g., amphetamines, opioids)
- Reduced evaporation times and lower processing temperatures
- Impact on sample integrity and cross-contamination risk
Comparative testing showed higher sensitivity for a range of controlled substances, including amphetamines and opioids, alongside reduced evaporation times and lower processing temperatures.