Hull LyoConstellation™ S10/S20/S30 Pilot Lyophilizers

If you need a lyophilizer that slots into your fill-finish workflow and is cleanroom ready, Hull LyoConstellation™ S10/S20/S30 Pilot Lyophilizers are here to help.

LyoConstellation pilot lyophilizers build on SP’s reputation as a pioneer of freeze-drying technologies. Designed to GMP standards and ready for full line integration, the LyoConstellation fits in where others cannot. And, with our comprehensive and innovative range of Line of Sight™ Lyophilization and PAT Tools for your high-value products, we’ve done the hard work, so you don’t have to.

Features & Benefits

Taking you from start to finish — ideal for cycle development and scale-up to stability, pilot, and clinical batch production, through full aseptic production
Technologies that ensure quality — full suite of PAT tools and technologies enables Line of Sight approach in cycle development and scale-up for simplified technology transfer, assuring product safety and quality in production
Validation made easy — validation ports in chamber and condenser as standard, with full documentation package and support available
Accurate end points — Pirani gauge and capacitance manometer as standard
Built for demanding lyophilization needs — each of our units accommodate vials up to 30 mL and can hold 100 mTorr while shelves are at +40⁰C fully loaded
Full Steam in Place (SIP) & Clean in Place (CIP) execution, with manual/H₂O₂ option
Isolator ready with auto locking doors

Line of Sight™ Lyophilization & PAT Tools

To help you overcome the mounting challenges when scaling up your lyophilization processes, LyoConstellation™ lyophilizers are compatible with our state-of-the-art Line of Sight™ Lyophilization and Process Analytical Technologies (PAT) suite of scalable tools:

LyoFlux® TDLAS — measure water vapor mass flow with accuracy during freeze-drying
SMART™ Freeze Dryer Technology — get instant feedback on important product data including resistance, heat flow, and mass transfer
TEMPRIS® Wireless Sensors — advanced wireless temperature monitoring for the highest quality product, on budget and on time
ControLyo® Nucleation Technology — take control of your freeze-drying with cutting-edge nucleation technology for precise control of the freezing point

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