Impact of Freeze-Drying Process and Lyoprotectants on Nanoparticle Stability

Freeze-drying is an effective approach to improve the storage stability of nanomedicines. The optimal freeze-drying process and lyoprotectants for three types of nanoparticles: solid lipid nanoparticles, polymeric nanoparticles, and liposomes were investigated. It was identified that various nanoparticle platforms have different behaviors in the freeze-drying process and require appropriate approaches to cope with. The impact of lyoprotectant selection and freeze-drying process on nanoparticle stability will be presented. Presented by Dr. Xiuling Lu, Associate Professor of Pharmaceutics in the School of Pharmacy at the University of Connecticut