Lyophilization (freeze-drying) of high concentration protein formulations often results in cakes with long and variable reconstitution times. Presence of crystalline mannitol in the freeze-dried cakes has been indicated to improve the reconstitution time when compared to cakes in which mannitol remains fully amorphous. However, reasons underlying the significant improvement offered by crystalline mannitol are yet to be fully elucidated. The webinar will address the mechanisms by which crystalline mannitol improves reconstitution time by providing a fundamental understanding of the contribution of mannitol crystallinity towards the cake attributes influencing reconstitution. Presented by Shreya Kulkarni, PhD Research Investigator in the Drug Product Development department at Bristol-Myers Squibb
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