Efficient recovery of radio-labelled metabolites from biological samples is critical for accurate ADMET assessment. This article demonstrates that using a high-g-force Genevac HT-4 centrifugal evaporator with Luma Plates significantly increases scintillation sensitivity and metabolite recovery in microplate assays. The centrifugal action concentrates the scintillant–sample mixture into a compact pellet, improving photon detection and reducing analysis time. Comparative testing confirmed superior sensitivity, reproducibility, and throughput, establishing the approach as a reliable enhancement for radiometric metabolite quantification in drug discovery workflows.
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